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APMIS. 2010 Sep 1;118(9):665-73.
Persistence of borrelial DNA in the joints of Borrelia burgdorferi-infected mice after ceftriaxone treatment.
Yrjänäinen H, Hytönen J, Hartiala P, Oksi J, Viljanen MK.

Department of Medical Microbiology and Immunology, University of Turku, Finland. heta.yrjanainen@utu.fi
Abstract
We have earlier shown that Borrelia burgdorferi-infected and ceftriaxone-treated mice have viable spirochetes in their body, since immunosuppressive treatment allows B. burgdorferi to be detected by culture. However, the niche of the persisting spirochetes remained unknown. In the present study, we analyzed the tissues of B. burgdorferi-infected and ceftriaxone-treated mice by culture and PCR to reveal the foci of persisting spirochetes. C3H/HeN mice were infected via intradermal needle injection with B. burgdorferi s.s. N40. The mice were treated as follows: (i) short (5 days) and (ii) long (18 days) course of ceftriaxone at 2 weeks of infection and killed after either 10 or 30 weeks, or (iii) the mice received ceftriaxone for 5 days at 18 weeks of infection and were killed 21 weeks after the treatment. All samples of ceftriaxone-treated mice were culture negative, whereas all untreated controls were culture positive. Importantly, B. burgdorferi DNA was detected in the joints of 30-100% of the treated mice. In conclusion, these results combined with earlier results suggest that the joint or a tissue adjacent to the joint is the niche of persisting B. burgdorferi in ceftriaxone-treated mice.

PMID: 20718718 [PubMed - indexed for MEDLINE]

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http://www.ncbi.nlm.nih.gov/pubmed/20718718

[Agnès]

merci pour cet article !!

[gégé]

Hello,

malgré le traductor j'ai pas tout capté,

en gros, la persistance serai due au traitement au ceftriaxone , c'est çà ? ou j'ai tout faux.

gégé

[annie]

the joint or a tissue adjacent to the joint is the niche of persisting B. burgdorferi in ceftriaxone-treated mice.

la borreliose reste dans les articulations des souris ou le les tissus adjacents chez les souris ayant été traitées par le ceftriaxone

[cannelle2010]

oui, merci annie!

serait-ce le meme genre de reaction qui fait que , depuis le debut des traitements, pour moi beaucoup de symptomes s'ameliorent, alors que....les articulations sont BEAUCOUP plus douloureuses et bloquees...??j'en discuterai avec le doc dans 10 jours... a suivre!