preuves de l'infection persistante dans la maladie de Lyme
Posté : 04 juin 2013 23:37
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636972/
Review of evidence for immune evasion and persistent infection in Lyme disease
Review of evidence for immune evasion and persistent infection in Lyme disease
Int J Gen Med. 2013; 6: 291–306.
Published online 2013 April 23. doi: 10.2147/IJGM.S44114
PMCID: PMC3636972
Review of evidence for immune evasion and persistent infection in Lyme disease
Keith Berndtson
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Abstract
Is chronic illness in patients with Lyme disease caused by persistent infection? Three decades of basic and clinical research have yet to produce a definitive answer to this question. This review describes known and suspected mechanisms by which spirochetes of the Borrelia genus evade host immune defenses and survive antibiotic challenge. Accumulating evidence indicates that Lyme disease spirochetes are adapted to persist in immune competent hosts, and that they are able to remain infective despite aggressive antibiotic challenge. Advancing understanding of the survival mechanisms of the Lyme disease spirochete carry noteworthy implications for ongoing research and clinical practice.