Re: Forme enkystée.
Posté : 30 déc. 2016 21:21
Personnellement je pense que ceux qui ont été traités et guéris en première intention, ne sont pas sur ce forum.
Flam
Flam
Sourcethe addition of either daunomycin or daptomycin to the doxycycline + cefuroxime combination completely eradicated the biofilm-like structures and produced no visible bacterial regrowth after 7 and 21 days
SourceDaptomycin plus doxycycline and cefoperazone eradicated the most resistant microcolony form of B. burgdorferi persisters and did not yield viable spirochetes upon subculturing, suggesting durable killing that was not achieved by any other two or three drug combinations.
Encore une fois, on ne peut comparer que ce qui est comparable!Flam a écrit :Personnellement je pense que ceux qui ont été traités et guéris en première intention, ne sont pas sur ce forum.
Flam
Source: https://www.ncbi.nlm.nih.gov/pubmed/19899620Ciprofloxacin/N-acetylcysteine showed the highest inhibitory effect on biofilm production (94-100%) and the highest disruptive effect on the pre-formed biofilms (86-100%) [...] In conclusion, Ciprofloxacin/N-acetylcysteine combinations have the highest inhibitory effect on biofilm production and the highest ability to eradicate pre-formed mature biofilms.
Source: https://www.ncbi.nlm.nih.gov/pubmed/25339490NAC, in combination with different antibiotics, significantly promoted their permeability to the deepest layers of the biofilm, overcoming the problem of the resistance to the classic antibacterial therapeutic approach.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095124/The daptomycin/doxycycline combined with cefoperazone or cefuroxime is the most effective drug combination which could eradicate even the most resistant aggregated microcolony form of B. burgdorferi enriched in stationary phase cultures
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095124/We found the triple drug combination treatment (ceftriaxone/doxycycline/daptomycin) without pulse dosing was the most effective among all drug combinations tested and was more active (residual viability 19%) than the same triple drug combination with pulse dosing treatment (residual viability 42%). The three drug combination treatment without pulse dosing eradicated virtually all visible B. burgdorferi cells including the aggregated microcolony form
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373819/The best result was achieved with daptomycin in combination with doxycycline and cefoperazone, which killed all B. burgdorferi persisters with no viable bacteria observed [...] Importantly, this drug combination could eliminate not only planktonic stationary phase B. burgdorferi persisters (spirochetal and round body forms) but also the more resistant biofilm-like microcolonies
Source: https://www.ncbi.nlm.nih.gov/pubmed/26903956The two drug combination of doxycycline and cefuroxime was unable to eradicate biofilm-like microcolonies of B. burgdorferi persisters. However, the addition of either daunomycin or daptomycin to the doxycycline + cefuroxime combination completely eradicated the biofilm-like structures and produced no visible bacterial regrowth after 7 and 21 days, while the addition of doxorubicin was unable to prevent regrowth
Léa,Léa a écrit :Flam : Il y a aussi ceux très nombreux aidés tant par les associations, ce forum ou simplement par un malade lambda qui se révèlent être des vraies sangsues, promettant monts et merveilles lorsqu'ils iront mieux, mais qui, une fois "allant mieux" n'en ont rien à faire des autres et surtout pas investis par la CAUSE!