EPP contre les borrélies enkystées
Posté : 30 oct. 2012 21:27
http://www.lyme.ws/grapefruit-seed-extract-is-a-powerful-in-vitro-agent-against-motile-and-cystic-forms-of-borrelia-infection/
Grapefruit Seed Extract is a Powerful In Vitro Agent Against Motile and Cystic Forms of Borrelia Infection
Grapefruit Seed Extract is a Powerful In Vitro Agent Against Motile and Cystic Forms of Borrelia Sensu Lato Infection
Brorson O, Brorson SH.
Lyme borreliosis [1], caused by B. burgdorferi sensu lato, may lead to long-term tissue infection, which may be difficult to cure. The outcome of Lyme borreliosis is highly dependant on the antibiotic treatment [2]. The observation of the ability of B. burgdorferi sensu lato to convert (and reconvert) to cystic forms [3–5] may explain why the infection sometimes is persistent and reactivating.
Therefore, it might be important to eradicate all germative forms (not only the motile form) of the bacterium to obtain a proper treatment for Lyme borreliosis. Grapefruit-seed extract (GSE) contains bioactive flavenoids (e.g., hesperitin, resveratrol, and naringenin) and has been shown to possess anti-microbiological effect against bacteria and fungus [6,7]. Many studies indicate that GSE is a substance whose therapeutic effect ranks equal to or better than other known anti-bacterial agents.
Conclusion: The highest GSE concentrations made the bacteria and cysts disappear completely, leaving only small uncharacteristic fragments; at lower GSE-levels the membranes showed herniation and disruption, and the contents had leaked out. The MBC was strongly dependent on the length of the incubation. GSE was very active even for very short incubation times, in agreement with previous results [7].
The MBC obtained by DFM (dark-field-microscopy) for the motile bacteria agreed well with the TEM results. Presence of GSE reduced the conversion from spirochetes to cysts when the susceptibility testing was performed in distilled water.
This study was performed in vitro and further studies are needed to demonstrate eventual effects in vivo. From our results it will be rational to test the hypothesis that a combination of GSE and antibiotics will be efficient in the treatment of resistant Lyme borreliosis.