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MessagePublié: 24 Juin 2010 16:05 
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Enregistré le: 06 Juil 2006 17:24
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FDA and NIH confirm WPI XMRV findings

http://feedproxy.google.com/~r/Virology ... dium=email

Posted: 22 Jun 2010 03:18 PM PDT

A press release http://www.mmdnewswire.com/xmrv-9040.html from the Netherlands indicates that the FDA and NIH have independently confirmed the association of XMRV with chronic fatigue syndrome as published last fall in Science. Apparently two journalists for the Dutch magazine ORTHO obtained a copy of a lecture by Dr. Harvey Alter in Zagreb which confirms these findings. According to Newswire.com:

The ORTHO journalists were able to obtain a pdf document of the lecture given by Harvey Alter at the IPFA/PEI 17th Workshop on ‘Surveillance and screening of Blood Borne Pathogens’ in Zagreb. The International Plasma Fractionation Association (IPFA) represents the not-for-profit organizations around the world involved in plasma fractionation. The IPFA is based in Amsterdam, the Netherlands.

The highly-experienced Dr. Harvey Alter is Clinical Studies Chief at the Infectious Diseases and Immunogenetics Section of the Department of Transfusion Medicine at the NIH Clinical Center in Bethesda. “The data in the Lombardi, et al Science manuscript are extremely strong and likely true, despite the controversy”, was one comment on the XMRV findings reported by Alter in Zagreb. “Although blood transmission to humans has not been proved, it is probable. The association with CFS is very strong, but causality not proved. XMRV and related MLVs are in the donor supply with an early prevalence estimate of 3%-7%. We (FDA & NIH) have independently confirmed the Lombardi group findings.”ORTHO contacted Dr. Harvey Alter today for a reaction. He did not want to comment, but confirmed that a paper is soon to be published.

I’m not entirely sure what it means to have confirmed the Lombardi group findings. Did the FDA and NIH use the same clinical specimens, or independently collected ones? We’ll have to wait for the article to appear to find out.

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MessagePublié: 24 Juin 2010 19:41 
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Enregistré le: 01 Fév 2009 22:06
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Merci Nelly

oui, attendons l'article du monsieur......comme c'est écrit...peut être?????

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MessagePublié: 03 Sep 2010 16:54 
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Enregistré le: 08 Fév 2007 01:55
Messages: 2592
Localisation: Tatooine
http://www.lepoint.fr/chroniqueurs-du-p ... 072_57.php

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MessagePublié: 03 Sep 2010 17:00 
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Enregistré le: 03 Juin 2010 06:18
Messages: 18
même si ça n'a pas encore l'air d'être prouvé, ça me laisse songeur quand aux pseudos diagnostiques de psychosomatique et de fibro... quand on se donne les moyens de chercher, on finit par trouver.


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MessagePublié: 05 Sep 2010 12:33 
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Enregistré le: 08 Fév 2007 01:55
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http://www.lemonde.fr/planete/article/2 ... _3244.html

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MessagePublié: 05 Sep 2010 12:41 
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Enregistré le: 08 Fév 2007 01:55
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Et ce qu'en pense le Dr Burrascano :

http://flash.lymenet.org/scripts/ultima ... 098080;p=0

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MessagePublié: 16 Sep 2010 13:55 
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Enregistré le: 08 Fév 2007 01:55
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Quelques nouvelles :

http://www.cfscentral.com/2010/09/dr-pa ... ation.html

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MessagePublié: 16 Oct 2010 17:14 
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Enregistré le: 08 Fév 2007 01:55
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Citer:
PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.
Satterfield BC, Garcia RA, Gurrieri F, Schwartz CE.

Abstract
ABSTRACT: Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus implicated in prostate cancer and chronic fatigue syndrome (CFS). Press releases have suggested that it could contribute to autism spectrum disorder (ASD). In this study we used two PCR assays and one antibody assay to screen 25 blood samples from autistic children born to mothers with CFS and from 20 mixed controls including family members of the children assayed, people with fibromyalgia and people with chronic Lyme disease. Using a real-time PCR assay, we screened an additional 48 South Carolina autism disorder samples, 96 Italian ASD)samples, 61 South Carolina ASD samples and 184 healthy controls. Despite having the ability to detect low copy number XMRV DNA in a large background of cellular DNA, none of the PCR assays found any evidence of XMRV infection in blood cells from patients or controls. Further, no anti-XMRV antibodies were detected, ruling out possible low level or abortive infections in blood or in other reservoirs. These results imply that XMRV is not associated with autism.

PMID: 20946639 [PubMed - as supplied by publisher]


http://www.ncbi.nlm.nih.gov/pubmed/20946639

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MessagePublié: 17 Fév 2011 17:39 
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Enregistré le: 08 Fév 2007 01:55
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http://jvi.asm.org/cgi/content/abstract/JVI.02411-10v1

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Infection, viral dissemination and antibody responses of Rhesus macaques exposed to the human gammaretrovirus XMRV
Nattawat Onlamoon, Jaydip Das Gupta, Prachi Sharma, Kenneth Rogers, Suganthi Suppiah, Jeanne Rhea, Ross J. Molinaro, Christina Gaughan, Beihua Dong, Eric A. Klein, Xiaoxing Qiu, Sushil Devare, Gerald Schochetman, John Hackett Jr., Robert H Silverman, and François Villinger*
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta GA; Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA; Glickman Urological and Kidney Institute and LRI, Cleveland Clinic Foundation, Cleveland, OH; Abbott Diagnostics, Emerging Pathogens and Virus Discovery, Abbott Park, IL
* To whom correspondence should be addressed. Email: fvillin@emory.edu.



Abstract
XMRV was identified in association with human prostate cancer and chronic fatigue syndrome. To examine the infection potential, kinetics, and tissue distribution of XMRV in an animal model, we inoculated 5 macaques with XMRV intravenously. XMRV established a persistent chronic disseminated infection, with low transient viremia and provirus in blood lymphocytes during acute infection. Although undetectable in blood after about a month, XMRV viremia was reactivated at 9 month confirming the chronicity of the infection. Furthermore, XMRV gag was detected in tissues throughout, with wide dissemination throughout the entire period of monitoring. Surprisingly, XMRV infection showed organ specific cell tropism: CD4 T cells in lymphoid organs including the gastrointestinal lamina propria, alveolar macrophages in lung, and epithelial/interstitial cells in other organs, including the reproductive tract. Of note, in spite of the intravenous inoculation, extensive XMRV replication was noted in prostate during acute but not chronic infection, even though infected cells were still detectable by FISH in prostate at 5 and 9 months post infection. Marked lymphocyte activation occurred immediately post infection, but antigen specific cellular responses were undetectable. Antibody responses were elicited and boosted upon reexposure, but titers decreased rapidly suggesting low antigen stimulation over time. Our findings establish a nonhuman primate model to study XMRV replication/dissemination, transmission, pathogenesis, immune responses and potential future therapies.

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