Tmt oral avec roxythromicine et co-trimexazole
Posté : 17 mai 2006 21:35
Ce traitement a l'air efficace, testé par un médecin autrichien je crois, donc pour souches europpéennes de borrelia.
La roxythromicine est le seul macrolide a pouvoir s'immiscer dans le système nerveux central, ce qui est le but recherché de pas mal d'entre nous...
J'amerais savoir si qqun a eu ce tmt.
Voici le topo en anglais :
Oral treatment of late borreliosis with roxithromycin
plus co-trimoxazole
SIR, - Early, but not late, Lyme borreliosis has been successfully
treated with oral antibiotics such as penicillins, erythromycin, and
tetracycline. The possibility of an oral treatement is desirable,
especially in view of the great difficulties that arise with long-lasting
intravenous treatment in third-world countries.(1, 2)
Various workers have shown relapses and failure of treatment in late
Lyme borreliosis(adrodermatitits chronica atrophicans, arthritis,
neuroborreliosis) even with high doses of intravenous penicillin or
ceftriaxone. (2, 3)
Treatment that is both orally applicable and effective is certainly
needed.(2) Co-trimoxazole is a powerful antibiotic combination to
which many microorganisms respond, including the spirochaete
Treponema pallidum. Furthermore, it has been show that the new
macrolides(such as roxithromycin) show a remarkable antimicrobial
activity angaint B burgdorferi.(4,5)
It is noteworthy that the blood/brain barrier is highly permeable
to roxithromycin.
A 30-year-old man infected with B burgdorferi 7 years ago was
successfully treated with a combination of roxithromycin(300 mg
twice daily) and trimethoprim/sulphamethoxazole(320 mg/1600 mg
twice daily) after both intraveous penicillin(20 million IU
daily ober 3 weeks) and later ceftriaxone 2 g twice daily for 3 weeks)
had failed (figure {not included} ). Both intravenous penicillin
and ceftriaxone reduced the symptoms transiently, while IgG remained
positive.
However, shortly after a 3-week course of roxithromycin/co-trimoxazole
all symptoms disappeared and a recent assessment of IgG revealed a
negative titre. The recovery of the patient's neurological
disorders was strikingly rapid, possibly because of the high
permeability of the blood/brain barrier to roxithromycin. Thus,
albeit in only 1 patient, we have shown successful oral treatment of
late Lyme borreliosis with a combination of roxithromycin and
co-trimoxazole.
@ +
La roxythromicine est le seul macrolide a pouvoir s'immiscer dans le système nerveux central, ce qui est le but recherché de pas mal d'entre nous...
J'amerais savoir si qqun a eu ce tmt.
Voici le topo en anglais :
Oral treatment of late borreliosis with roxithromycin
plus co-trimoxazole
SIR, - Early, but not late, Lyme borreliosis has been successfully
treated with oral antibiotics such as penicillins, erythromycin, and
tetracycline. The possibility of an oral treatement is desirable,
especially in view of the great difficulties that arise with long-lasting
intravenous treatment in third-world countries.(1, 2)
Various workers have shown relapses and failure of treatment in late
Lyme borreliosis(adrodermatitits chronica atrophicans, arthritis,
neuroborreliosis) even with high doses of intravenous penicillin or
ceftriaxone. (2, 3)
Treatment that is both orally applicable and effective is certainly
needed.(2) Co-trimoxazole is a powerful antibiotic combination to
which many microorganisms respond, including the spirochaete
Treponema pallidum. Furthermore, it has been show that the new
macrolides(such as roxithromycin) show a remarkable antimicrobial
activity angaint B burgdorferi.(4,5)
It is noteworthy that the blood/brain barrier is highly permeable
to roxithromycin.
A 30-year-old man infected with B burgdorferi 7 years ago was
successfully treated with a combination of roxithromycin(300 mg
twice daily) and trimethoprim/sulphamethoxazole(320 mg/1600 mg
twice daily) after both intraveous penicillin(20 million IU
daily ober 3 weeks) and later ceftriaxone 2 g twice daily for 3 weeks)
had failed (figure {not included} ). Both intravenous penicillin
and ceftriaxone reduced the symptoms transiently, while IgG remained
positive.
However, shortly after a 3-week course of roxithromycin/co-trimoxazole
all symptoms disappeared and a recent assessment of IgG revealed a
negative titre. The recovery of the patient's neurological
disorders was strikingly rapid, possibly because of the high
permeability of the blood/brain barrier to roxithromycin. Thus,
albeit in only 1 patient, we have shown successful oral treatment of
late Lyme borreliosis with a combination of roxithromycin and
co-trimoxazole.
@ +
Merci Anne ! suis allee voir par "la"....et vais voir par "ici' ! 
à vous 2!