En bref: l'Azithromycine diffuse bien ds le cerveau mais PAS ds le liquide céphalo-rachidien NI ds l'humeur aqueuse des yeux.
Nelly
http://aac.asm.org/cgi/reprint/40/3/825.pdf
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Mar. 1996, p. 825-826 Vol. 40, No. 3
0066-4804/96/$04.0010
Copyright q 1996, American Society for Microbiology
Distribution of Azithromycin into Brain Tissue, Cerebrospinal
Fluid, and Aqueous Humor of the Eye
SUTEP JARURATANASIRIKUL,1* RATRI HORTIWAKUL,1 THAWAT TANTISARASART,2
NAKORNCHAI PHUENPATHOM,3 AND SUKIT TUSSANASUNTHORNWONG3
Department of Medicine,1 Department of Ophthalmology,2 and Department of Surgery,3 Faculty of Medicine,
Prince of Songkla University, Hat Yai, Songkla 90112, Thailand
Received 7 June 1995/Returned for modification 4 September 1995/Accepted 10 December 1995
To measure the concentrations of azithromycin in the central nervous system, 20 patients with brain tumors
(group I) received a single 500-mg oral dose of azithromycin either 24, 48, 72, or 96 h prior to the tumor
removal operation and 10 patients with cataracts undergoing surgery (group II) and 7 patients scheduled to
undergo lumbar puncture (group III) received the same dose of azithromycin 24 h prior to the operation or
procedure. Serum from all patients, brain tissue from group I, aqueous humor from group II, and cerebrospinal
fluid from group III were assayed for azithromycin concentration. The mean concentrations of azithromycin
in brain tissue 24, 48, 72, and 96 h after administration were 2.63 6 2.58, 3.64 6 3.81, 0.74 6 0.37, and
0.41 mg/g, respectively. In contrast, the concentrations of azithromycin in cerebrospinal fluid and aqueous
humor of the eye were very low or undetectable. ****Therefore, these data show that azithromycin appears to be
widely distributed into brain tissue but not into cerebrospinal fluid or aqueous humor of the eye.*****